The Extracellular Matrix (ECM) is the "glue" that holds cells together allowing them to form tissue. Abnormalities in the ECM can be indicative of disease, for example cancer. Biofilms composed of bacteria are held together by ECM with its very presence being a factor in antimicrobial resistance. In my group we are interested in applying engineering and physics principles to understand the ECM and its role in disease. In particular we are studying

  • Targeting the ECM to treat cancer
  • Elucidating the role of the ECM in cancer cell invasion and metastasis
  • Understanding the role of matrix components in chemotherapy resistance
  • Determining the physics of biofilm formation
  • Developing methods to destroy biofilms

I am very much a hands on scientist and spend much of my time in the lab. Our expertise is in applying physics and engineering to biological systems. If you would like to join the group as either a PhD student or postdoc please send me an email.

Daniel Frankel